Researchers have developed a synthetic methylotrophic strain of S. cerevisiae capable of using methanol as a carbon source. By reconfiguring carbon metabolism and using adaptive laboratory evolution, the team overcame the toxicity of metabolic intermediates to produce chondroitin sulfate A. This advancement supports a methanol-based circular bioeconomy where captured greenhouse gases are converted into one-carbon compounds. This process allows for the sustainable biosynthesis of high-value chemicals, reducing reliance on traditional petroleum-based industrial precursors.
